“- Cruella De Vil: I want the job done tonight!
- Horace: How're we gonna do it?
- Cruella De Vil: Any way you like. Poison them. Drown them. Bash them in the head. You got any chloroform?”
Betty Lou Gerson - Cruella De Vil
Frederick Worlock - Horace

“- Lasky, Guard at Walleyworld: Has your father ever killed anyone?
- Rusty Griswold: Just a dog. Oh and my Aunt Edna.”
John Candy - Lasky, Guard at Walleyworld
Anthony Michael Hall - Rusty Griswold

“- Ruby Deagle: I want your dog.
- Billy Peltzer: Barney?
- Ruby Deagle: Give him to me. I'll take him to the kennel, they'll put him to sleep. It will be quick and painless compared to what I would do to him.”
Polly Holliday - Ruby Deagle
Zach Galligan - Billy Peltzer

“- Policeman with dog: You people are ought to stay back! Killer here loves to bite!
- Maximillian: So do I!”

Eddie Murphy - Maximillian

“- Drillbit Taylor: You'd be surprised, anything can be turned into a weapon of mayhem or destruction.
- Emmit: Even a puppy?
- Drillbit Taylor: Especially a puppy. The Germans used em' in World War I. De Hundin Schtorman, Lightning Dog. They'd attach dynamite to them.”
Owen Wilson - Drillbit Taylor
David Dorfman - Emmit