“- Raoul Duke: Straight economics, man. This girl is a godsend. Shit, she can make us a grand a day.
- Dr. Gonzo: That's ugly, man. Stop talking like that.
- Raoul Duke: I figure she can do about four at a time. If we keep her full of acid that's more like two grand a day. Maybe three.”
Johnny Depp - Raoul Duke
Benicio del Toro - Dr. Gonzo

“- Dick Jones: Delta City begins construction in two months. That's two million workers living in trailers. That means drugs, gambling, prostitution - virgin territory for the man who knows how to open up new markets. One man could control it all, Clarence.
- Clarence J. Boddicker: Well, I guess we're gonna be friends after all... Richard.”
Ronny Cox - Dick Jones
Kurtwood Smith - Clarence J. Boddicker

“- Simone: Sometimes they fall for what they think I am.
- George: And what do they think you are?
- Simone: What you think. A black whore.”
Cathy Tyson - Simone
Bob Hoskins - George

“What planet are you from, sugar tits? Saturn with the rings around your head?”

Penn Fraser Jillette - Bone

“- Rob: This is the Governor's wife!
- Deke Halliday: You mean she's not the hooker?
- Baxter: I told you not to wear those heels, darling.”
Dennis Dugan - Rob
Dick Shawn - Deke Halliday
Sir Michael Caine - Baxter