“You know how we're always saying what a pain you are, you're the world's worst dog, don't believe it, don't believe it for one minute because you know we couldn't find a better dog, I love you, more than anything, you're a great dog, I love you.”

Owen Wilson - John

“- Joseph: We haven't lost a person. We lost a dog.
- Beth: Love is love. It doesn't matter if it's a dog.”
Kevin Kline - Joseph
Diane Keaton - Beth

“You see a dog. I see an animal that believes with every fiber of his being that the girl he loves is in mortal danger. I see a depth of emotion on the face of that canine the likes of which has never been captured on screen before.”

James Lipton - The Director

“- Rick: Dex is just bitter because he's never been in love.
- Dex: I love my dog.”
David Aaron Baker - Rick
Donal Logue - Dex

“My family likes you more than they like me! Why? All you do is drool and shed and eat!”

Charles Grodin - George Newton