“- John Malkovich: I have seen a world that no man should see!
- Craig Schwartz: Really? Because for most people it's a rather enjoyable experience.”

John Malkovich - Himself
John Cusack - Craig Schwartz

“As I understand from your communication, Mr. Engle, you're on the brink of self-destruction. May I shake your hand? A brilliant idea! I speak as one who has destroyed himself a score of times.”

Thomas Mitchell - Gene Gibbons

“We're not just an uncle and a niece. It's something else. I know you. I know you don't tell people a lot of things. I don't either. I have a feeling that inside you there's something nobody knows about... something secret and wonderful. I'll find it out.”

Teresa Wright - Charlie Newton

“- Ray Bronson: No one gets me the way you do.
- Julie James: I understand your pain.”
Freddie Prinze Jr. - Ray Bronson
Jennifer Love Hewitt - Julie James

“- Dr. Alex Cross: Kate, I know how you feel, honestly.
- Dr. Kate McTiernan: Would you please stop treating me like I'm a victim? You think I'm some kind of tourist in all this because I wasn't raped? Every night when I go to sleep, I hear those women's voices. You want to save your niece? Guess what: so do I.”
Morgan Freeman - Dr. Alex Cross
Ashley Judd - Dr. Kate McTiernan