“- Rosalie Octavius: You need to sleep soundly tonight.
- Dr. Otto Octavius: Did Edison sleep before he turned on the light bulb? Did Marconi sleep before he turned on the radio? Did Beethoven sleep before he wrote the fifth?
- Peter Parker: Did Bernoulli sleep before he found the curves of quickest descent?”
Donna Murphy - Rosalie Octavius
Alfred Molina - Dr. Otto Octavius
Tobey Maguire - Peter Parker

“Would it not be the achievement of all time to keep the brains of great thinkers, scientists, authors, statesmen, alive? To derive benefit from their wisdom and thinking power, even after their death - to make them literally immortal?”
Erich von Stroheim - Prof. Franz Mueller

- Reporter: No offence, but NASA spends fifteen years, hundreds of millions of dollars so that we can watch man walk on the moon and in the end it falls to you, blokes! I mean, how do you feel about that?
- Ross "Mitch" Mitchell: A lot better before you opened your trap!
Kevin Harrington - Ross 'Mitch' Mitchell

“I’m a religious woman, there’s no question, but I have also been to medical school. And, well, you can say that I hold science in one hand and God in the other, and that is not always an easy balance.”
Cherry Jones - Dr. Muldoon

“Emily Stanton-Lydia, do you have any idea what you’ve done? I’ve worked for this my entire life, and you’ve ruined everything.
Lydia Berman-Oh, I don’t know what was in those needles, but I’m totally happy to give it back to you. I can like pee in a cup, or something.”
Melissa McCarthy - Lydia Berman
Octavia Spencer - Emily Stanton