“When a guy picks a chick over his buddies, something's gotta be wrong. Come on, guys let's go for some pizza.”
John Travolta - Danny

“- Karen Smith: God. My hips are huge!
- Gretchen Wieners: Oh please. I hate my calves.
- Regina George: At least you guys can wear halters. I've got man shoulders.
- Cady Heron: [voiceover] I used to think there was just fat and skinny. But apparently there's lots of things that can be wrong on your body.”
Amanda Seyfried - Karen Smith
Lacey Chabert - Gretchen Wieners
Rachel McAdams - Regina George
Lindsay Lohan - Cady Heron

“- Voice: There's someone in here.
- Christina: Sorry.
- Voice: It might be a while.
- Christina: How long?
- Voice: Let me put it to you this way. I had Lamb Curry last night and I'm shitting out a Buick!
- Courtney: Was it absolutely vital for her to tell us that?”

Cameron Diaz - Christina Walters

“- Rod Kimble: All great men have mustaches!
- Frank Powell: Yeah, but real men actually grow them!
- Rod Kimble: You know I have a hormone disorder!”
Andy Samberg - Rod Kimble
Ian McShane - Frank Powell

“- Dr. Nagato: You have arthritis in your knee.
- Josh: Arthritis arthritis?
- Dr. Nagato: Yes. I usually just say it once.”
James Saito - Dr. Nagato
Ben Stiller - Josh