- Mrs. Henry Vale: The very word "psychiatry", doesn't it fill you with shame, my daughter, a member of our family?
- Dr. Jaquith: There's nothing shameful or frightening about it. It's simple, what I do. People come to a fork in the road. They don't know which way to go. I put up a signpost: "Not that way. This way".

Gladys Cooper - Mrs. Henry Vale
Claude Rains - Dr. Jaquith

“- Rick Leland: You never have any clothes on.
- Alberta Marlow: If anyone heard you complaining about it, they would put you in a psychopathic ward.”
Humphrey Bogart - Rick Leland
Mary Astor - Alberta Marlow

“That insanity is a legal concept. It's not a medical or psychiatric term, but despite the fact that insanity's a legal concept, it doesn't mean that someone's not sick.”
Leelee Sobieski - Lauren Douglas

“Crazy people don't know they're crazy.”
Laura Linney - Erin Bruner

“You chose psychoanalysis over real life? Are you learning disabled?”
Woody Allen - David Dobel