“- Ellen Griswold: Gee Cath looks like you really got your hands full.
- Cousin Catherine: Oh, it's not so bad. Eddie says after the baby comes, I can quit one of my night jobs.”
Beverly D'Angelo - Ellen Griswold
Miriam Flynn - Cousin Catherine

“You're mother earth incarnate.”
Julia Roberts - Isabel Kelly

“- Ben Harrison: No one loves you like I do.
- Jackie Harrison: No. No one ever will.”
Liam Aiken - Ben Harrison
Susan Sarandon - Jackie Harrison

“You know every story, every wound, every memory. Their whole life's happiness is wrapped up in you.”
Julia Roberts - Isabel Kelly

- Isabel Kelly: Look down the road to her wedding. I'm in a room alone with her, fixing her veil, fluffing her dress, telling her no woman has ever looked so beautiful. And my fear is she'll be thinking, "I wish my mom was here”.
- Jackie Harrison: And mine is... she won't.
Julia Roberts - Isabel Kelly
Susan Sarandon - Jackie Harrison