“- Clark Griswold: Have you even driven cross-country?
- Roy Walley: Oh, hell yes. Drove the whole family to Florida. Worst two weeks I ever spent in my life.”
Chevy Chase - Clark Griswold
Eddie Bracken - Roy Walley

“- Rachel: Do you have a family?
- Harry Dalton: No.
- Rachel: Why not?
- Harry Dalton: Well, for one thing: I move around alot. Mexico, Alaska, South America, The Philippines, New Guinea, basically where there's a volcano with an attitude.”
Linda Hamilton - Rachel Wando
Pierce Brosnan - Harry Dalton

“Okay. Thanks to Sid, we're now traveling together, and, like it or not, we're gonna be one big, happy family. I'll be the daddy, Ellie will be the mommy, and Diego will be the uncle who eats the kids who get on my nerves.”
Ray Romano - Manny

“- Ducky: Where are we going?
- Littlefoot: To the Great Valley. I'm not gonna stop until I find my grandparents.”
Judith Barsi - Ducky
Gabriel Damon - Littlefoot

“- Audrey Griswold-Crandall: What kind of asshole would drive his family cross country?
- Rusty Griswold: Audrey, dad wanted us to be close and that's all I want for my family.
- Stone Crandall: Family is the most important thing there is.”
Leslie Mann - Audrey Griswold
Ed Helms - Rusty Griswold
Chris Hemsworth - Stone Crandall