“- Clark Griswold: Have you even driven cross-country?
- Roy Walley: Oh, hell yes. Drove the whole family to Florida. Worst two weeks I ever spent in my life.”
Chevy Chase - Clark Griswold
Eddie Bracken - Roy Walley

“My life was shaped because someone invented gunpowder, and that's what took me around the world. But the memory that I wanted, that was the family that I lost.”
Michael Douglas - Charles Remington

“- Rachel: Do you have a family?
- Harry Dalton: No.
- Rachel: Why not?
- Harry Dalton: Well, for one thing: I move around alot. Mexico, Alaska, South America, The Philippines, New Guinea, basically where there's a volcano with an attitude.”
Linda Hamilton - Rachel Wando
Pierce Brosnan - Harry Dalton

“- Ducky: Where are we going?
- Littlefoot: To the Great Valley. I'm not gonna stop until I find my grandparents.”
Judith Barsi - Ducky
Gabriel Damon - Littlefoot

“- Audrey Griswold-Crandall: What kind of asshole would drive his family cross country?
- Rusty Griswold: Audrey, dad wanted us to be close and that's all I want for my family.
- Stone Crandall: Family is the most important thing there is.”
Leslie Mann - Audrey Griswold
Ed Helms - Rusty Griswold
Chris Hemsworth - Stone Crandall