“- James Griswold: I've never even heard of the original vacation.
- Rusty Griswold: Doesn't matter. The new vacation will stand on its own.”
Skyler Gisondo - James Griswold
Ed Helms - Rusty Griswold

“- Roman: I think we should go into town tomorrow and pick up a ski boat. Whaddya say? Sound good, guys? Uncle Roman'll blow some coin on a kick-ass drag boat!
- Chet: That's ok, we're renting a pontoon boat.
- Roman: Pontoon boat? What the hell are you gonna do with a pontoon boat? Retake Omaha Beach?”
Dan Aykroyd - Roman Craig
John Candy - Chet Ripley

“- Jeff Badger: You are the sheriff wife now. It would be very embarrassing for you to know who I am.
- Flower Belle Lee: I've never been embarrassed in my life.”
Joseph Calleia - Jeff Badger
Mae West - Flower Belle Lee

“- Macaulay Connor: It can't be anything like love, can it?
- Tracy Lord: No, no, it can't be.
- Macaulay Connor: Would it be inconvenient?
- Tracy Lord: Terribly.”
James Stewart - Macaulay Connor
Katharine Hepburn - Tracy Lord

“- Lieutenant Stanislav Sobinski: I hope you'll forgive me if I acted a little clumsy, but this is the first time I ever met an actress.
- Maria Tura: Lieutenant, this is the first time I've ever met a man who could drop three tons of dynamite in two minutes.”
Robert Stack - Lieutenant Stanislav Sobinski
Carole Lombard - Maria Tura