“- Dr. John Dolittle: I didn't say you were crazy, you're special, and crazy, a lot of great people in history were crazy.
- Maya Dolittle: Like who?
- Dr. John Dolittle: Some of the greatest people in history.”
Eddie Murphy - Dr. John Dolittle
Kyla Pratt - Maya Dolittle

“All of us are freaks in one way or another.”
Sir John Hurt - The Countess

“- Vice President: What kind of lunatic are you?
- Joshua Foss: The best kind!”
Raymond J. Barry - Vice President
Powers Boothe - Joshua Foss

“- Mitch: Kenny has to go. He's cooking breakfast for his underwear.
- Dr. Jeffrey Sanborn: Who is this?
- Mitch: I'm a pair of his socks.”

Billy Crystal - Mitch Robbins
Bob Balaban - Dr. Jeffrey Sanborn

“Walter, you're wonderful, in a loathsome sort of way.”
Rosalind Russell - Hildy Johnson