“- James Griswold: I've never even heard of the original vacation.
- Rusty Griswold: Doesn't matter. The new vacation will stand on its own.”
Skyler Gisondo - James Griswold
Ed Helms - Rusty Griswold

“- Inspector Arthur Steed: And there's nothing left but to stop you.
- Maud Watts: What are you gonna do? Lock us all up? We're in every home, we're half the human race, you can't stop us all.”

Brendan Gleeson - Inspector Arthur Steed
Carey Mulligan - Maud Watts

“- Timon: That worked like a dream.
- Pumbaa: It did?
- Timon: Sarcasm is a foreign language to you, isn't it?”

Nathan Lane - Timon
Ernie Sabella - Pumbaa

“- Moly: You guys are top-flight security, best in the whole wide world. You have to defend this whole place with your own lives.
- Day-Day: And I'd die for this shit too. ”
Maz Jobrani - Moly
Mike Epps - Day-Day

“Douche-bags are hygienic products; I take that as a compliment. Thank you.”
Gabriel Millman - Keith - Caped Boy