“- Jared Grace: I don't want to live with dad. Is it okay if I stay here with you.
- Helen Grace: Who else is gonna protect us?”
Freddie Highmore - Jared Grace
Mary-Louise Parker - Helen Grace

“- Mrs. Devereaux: Trish, the chips are under the sink and there's soda in the fridge, and our number at the hotel is right by the phone.
- Trish: Okay, Mom, everything will be fine.”
Anna Patton - Mrs. Devereaux
Michelle Michaels - Trish

“The things I did, the things I've seen, it becomes who you are. You can't just go home and scrub it off. The only way I could protect you was to walk away. Forget about you and your mom. I wanted a better life for you than the one I chose for myself.”

Liam Neeson - Jimmy Conlon

“- Rose Darko: Our son just called me a bitch.
- Eddie Darko: You're not a bitch. You're bitchin', but you're not a bitch.”
Mary McDonnell - Rose Darko
Holmes Osborne - Eddie Darko

“- Donnie Darko: How's it feel to have a wacko for a son?
- Rose Darko: It feels wonderful.”
Jake Gyllenhaal - Donnie Darko
Mary McDonnell - Rose Darko