“- Jonesy: You don't smoke anymore.
- John Hobbes: You're right I don't. You know why? Because cigarettes kill. Especially cigarettes laced with poison.
- Jonesy: Bullshit.
- John Hobbes: The same kind of poisons you used to kill my brother.”

John Goodman - Jonesy
Denzel Washington - John Hobbes

“Yesterday, I learned how to poison mice. Field mice girdle an apple tree; pine mice kill the roots. You use poison oats and poison corn. I know what you have to do. You have to play God. Well, killing mice is as close as I want to come to playing God.”

Tobey Maguire - Homer Wells

“I baked a pie full of rat poison. I though I could eat it, you know, without being suspicious. My nana, who is 86... she really likes sweets. She had three pieces.”
Leah Straatsma - Rannie

“Sometimes, I'd like to push his poison down his own throat.”

Clark Gable - Christian

“- Cruella De Vil: I want the job done tonight!
- Horace: How're we gonna do it?
- Cruella De Vil: Any way you like. Poison them. Drown them. Bash them in the head. You got any chloroform?”
Betty Lou Gerson - Cruella De Vil
Frederick Worlock - Horace