“- Deke Slayton: Jan, you have to trust us. We've got this under control.
- Janet Armstrong: No, you don't. All these protocols and procedures to make it seem like you have it under control. But you're a bunch of boys making models out of balsa wood! You don't have anything under control!”
Kyle Chandler - Deke Slayton
Claire Foy - Janet Armstrong

“The animals keep checking in, but they don't check out, do they? You're not a scientist, you're an undertaker!”

Réal Andrews - Mark

“Hey Oppenheimer! Oppenheimer! You ought to stop playing God, because you're not good at it, and the position's taken!”
John C. McGinley - Richard Schoenfield

“Scientists predicted a light show of stellar proportions, something not seen on earth for 65 million years, indeed not since the time that the dinosaurs disappeared, virtually overnight. There were a few who saw this as more than just a coincidence, but most didn't...”
Michael Hanks - Narrator

“- Perfect Tommy: Emilio Lizardo. Wasn't he on TV once?
- Buckaroo Banzai: You're thinking of Mr. Wizard.
- Reno Nevada: Emilio Lizardo is a top scientist, dummkopf.
- Perfect Tommy: So was Mr. Wizard.”
Lewis Smith - Perfect Tommy
Peter Weller - Buckaroo Banzai
Pepe Serna - Reno Nevada